Lupron® (leuprolide acetate)

What is Lupron?


Lupron® is a gonadotropin-releasing hormone agonist. It inhibits the pituitary gland’s ability to control the ovary and, therefore, is used to treat endometriosis. In women with endometriosis, Lupron® provides pain relief and reduction in the size of endometriosis lesions. The drug is also used as part of the process to stimulate multiple eggs for assisted reproductive technologies.


How Do I Use Lupron?

Here are step-by-step instructions for taking Lupron® (leuprolide acetate) injections:

Lupron® is injected subcutaneously—or into the fatty tissue under your skin. The primary sites for injection are your abdomen—2 inches on either side of the navel—and your upper, outer-thigh where the skin is loose. Wash your hands thoroughly and make sure that the surface you work on is clean.


Use an alcohol swab to cleanse the rubber stopper of the vial.


Pull the plunger of the syringe back to the appropriate marking.

Pull off the cap of the needle, and pierce the rubber stopper of the Lupron® vial.


Push the plunger all the way in. Keeping the needle inside the bottle, turn the vial upside down. With the needle in the liquid, pull back the plunger, until the syringe fills to the proper mark.


Remove the needle from the vial, and prepare to administer the injection.

With the needle pointing toward the ceiling, flick the side of the syringe to disperse any air bubbles and the air pocket at the top of the syringe, then gently push the plunger until one or two drops of liquid are expressed to make sure you have eliminated any air.


Gently push on plunger until air pocket is gone and expel a drop of liquid.

How to give a subcutaneous injection


There are three places that a subcutaneous injection may be given: the abdomen, the thigh, or the back of your arm as shown here


Select your injection site (the abdomen is preferred)


Cleanse the area with alcohol and let dry. Do not blow on it.

Take a pinch of the fatty tissue you have cleansed. The injection is given here.


Hold the syringe like a pencil or a dart approximately 1 inch away from the skin.

Insert the needle quickly (not hard), with one fluid motion, into the skin.


Let go of the pinch of skin. Depress the plunger and inject all of the medication. Pull the needle straight out.


Apply pressure to the injection site with a sterile gauze pad.

Never reuse needles or syringes.


Dispose of the syringe in a biohazard container such as a Sharps container – or in a sealable, unbreakable plastic container such as a laundry detergent bottle.

Please be aware that some of these instructions may vary based on your particular situation or preference.